The National Science Foundation (NSF) awarded a research grant, in the expected amount of $500,000, to Ben Raphael and Eli Upfal to develop robust algorithmic and statistical techniques for the analysis of DNA sequence variants in the context of known and novel gene-gene interactions. These techniques will allow biomedical researchers to identify DNA variants associated with risk for various diseases, including cancer. Algorithms developed in this project will be implemented and released as open-source software for use by the biological and medical community. The project will also support the training of graduate students and undergraduate researchers.